Role of titin in skeletal muscle sarcomere
structure and function
Copyright (C) 2023, Department of Nutrition and Metabolism, Institute of Biomedical Sciences,
Tokushima University Graduate School. All Rights Reserved.
Urinary titin as an early biomarker of skeletal muscle proteolysis and atrophy in various catabolic conditions
1-s2.0-S0006291X24014542-ga1_lrg.jpg (1633×886)
Hyodo M, Nomura K, Tsutsumi R, Izumi-Mishima Y, Kawaguchi H, Kawakami A, Hara K, Suzuki Y, Shirakawa T, Osawa K, Matsuo M, Sakaue H. .Biochem Biophys Res Commun. 737:150918 2024
Urinary level of titin, a muscle damage marker,
is associated with sarcopenia in diabetes
Y Takiguchi, R Tsutsumi, M Shimabukuro, H Tanabe, A Kawakami, M Hyodo, K Shiroma, H Saito, M Matsuo, H Sakaue
J Endocrinol Invest. 2024 Nov 16. doi: 10.1007/s40618-024-02490-4. Online ahead of print. PMID: 39549212 DOI: 10.1007/s40618-024-02490-4
A conceptual image of urinary titin N-fragment
and muscle weakness in PICS
Figure 2. This is a conceptual image of urinary titin N-fragment and muscle weakness in PICS.
Urinary Titin N-Fragment as a Biomarker of Muscle Atrophy, Intensive Care Unit-Acquired Weakness, and Possible Application for Post-Intensive Care Syndrome.
Nakanishi N, Tsutsumi R, Hara K, Matsuo M, Sakaue H, Oto J. J Clin Med. 2021 Feb 6;10(4):614. doi: 10.3390/jcm10040614. PMID: 33561946
Joint Meetings
９．1st (Digestive B) Section Meeting (Teams) 2024.10.30
８．3st (Digestive A) Section Meeting (Teams) 2024.10.10
７．2st (Digestive A) Section Meeting (Teams) 2024.9.30
６．1st (Digestive A) Section Meeting (Teams) 2024.5.9
５．2nd (Diabetes and Exercise) Section Meeting (Tokushima) 2024.2.3
４．1st (expanded) group meeting (Kobe) 2023.1.31
３．3rd Pre-Meeting (Okinawa) ） 2022.12.2
２．2rd Pre-Meeting (Kobe) 2022.11.11
１．1rd Pre-Meeting (Tokushima) 2022.8.22
Publications
８．【Calpain3 and urinary titin】The N-terminal Fragment of Urine Titin is Not a Product of degradation by Calpain 3
Muscle & Nerve in press
【Cluster Affiliated Researchers：Machida K, Tsutsumi R, Sakaue H, Matsuo M】
７．【Diabetes】Urinary level of titin, a muscle damage marker, is associated with sarcopenia in diabetes: a propensity score matching analysis
Y Takiguchi, R Tsutsumi, M Shimabukuro, H Tanabe, A Kawakami, M Hyodo, K Shiroma, H Saito, M Matsuo, H Sakaue
J Endocrinol Invest. 2024 Nov 16. doi: 10.1007/s40618-024-02490-4. Online ahead of print. PMID: 39549212 DOI: 10.1007/s40618-024-02490-4
【Cluster Affiliated Researchers：Tsutsumi R, Shimabukuro M, Kawakami A, Hyodo M, Matsuo M, Sakaue H】
６．【Animal models】Urinary titin as an early biomarker of skeletal muscle proteolysis and atrophy in various catabolic conditions.
Hyodo M, Nomura K, Tsutsumi R, Izumi-Mishima Y, Kawaguchi H, Kawakami A, Hara K, Suzuki Y, Shirakawa T, Osawa K, Matsuo M, Sakaue H.
Biochem Biophys Res Commun. 2024 Dec 10;737:150918. doi: 10.1016/j.bbrc.2024.150918. Epub 2024 Oct 28.
【Cluster Affiliated Researchers：Hyodo M, Nomura K, Tsutsumi R, Izumi-Mishima Y, Kawaguchi H, Kawakami A, Hara K, Suzuki Y, Matsuo M, Sakaue】
５．【Myocardial infarction】The Utility of Urinary Titin to Diagnose and Predict the Prognosis of Acute Myocardial Infarction.
Arase M, Nakanishi N, Tsutsumi R, Kawakami A, Arai Y, Sakaue H, Oto J.
Int J Mol Sci. 2024 Jan 1;25(1):573. doi: 10.3390/ijms25010573. PMID: 38203744
【Myopathy Diagnostic Cluster Affiliated Researchers：Tsutsumi R, Kawakami A, Sakaue H, Oto J】
４．【Infant】Assessment of catabolic state in infants with the use of urinary titin N-fragment.
Fukushima S, Nakanishi N, Fujioka K, Suga K, Shirakawa T, Osawa K, Hara K, Tsutsumi R, Urushihara M, Nakagawa R, Awano H, Oto J, Sakaue H, Iijima K, Matsuo M. Pediatr Res. 2021 Jul 17. doi: 10.1038/s41390-021-01658-5. PMID: 34274960
【Cluster Affiliated Researchers：Hara K, Tsutsumi R, Oto J, Sakaue H, Matsuo M】
３．【Review: Sepsis/PICS】Urinary Titin N-Fragment as a Biomarker of Muscle Atrophy, Intensive Care Unit-Acquired Weakness, and Possible Application for Post-Intensive Care Syndrome.
Nakanishi N, Tsutsumi R, Hara K, Matsuo M, Sakaue H, Oto J. J Clin Med. 2021 Feb 6;10(4):614. doi: 10.3390/jcm10040614. PMID: 33561946
【Cluster Affiliated Researchers：Tsutsumi R, Hara K, Matsuo M, Sakaue H, Oto J】
２．【Stroke】Elevated Urinary Titin and its Associated Clinical Outcomes after Acute Stroke.
Ishihara M, Nakanishi N, Tsutsumi R, Hara K, Machida K, Yamamoto N, Kanematsu Y, Sakaue H, Oto J, Takagi Y. J Stroke Cerebrovasc Dis. 2020 Dec 23;30(3):105561. doi:10.1016/j.jstrokecerebrovasdis.2020.105561. PMID: 33360523
【Cluster Affiliated Researchers：Tsutsumi R, Hara K, Machida K, Sakaue H, Oto J】
１．【Sepsis】Urinary Titin Is a Novel Biomarker for Muscle Atrophy in Nonsurgical Critically Ill Patients: A Two-Center, Prospective Observational Study.
Nakanishi N, Tsutsumi R, Hara K, Takashima T, Nakataki E, Itagaki T, Matsuo M, Oto J, Sakaue H.
Crit Care Med. 2020 Jul 16. doi: 10.1097/CCM.0000000000004486. PMID: 32706557
【Cluster Affiliated Researchers：Tsutsumi R, Hara K, Matsuo M, Oto J, Sakaue H】
Conference Presentations
３．第9回日本筋学会
兵藤瑞沙「骨格筋萎縮のバイオマーカーとしての尿中タイチン測定の有用性」
２．第26回日本病態栄養学会【YIA特別賞受賞】
鈴木由紀「重症病態における筋萎縮と尿中タイチン濃度測定の意義」
１．第55回 日本栄養・食糧学会【中国・四国支部大会学生奨励賞受賞】
兵藤瑞沙「骨格筋萎縮のバイオマーカーとしての尿中タイチン測定の有用性」
Research Meeting Presentations
３．DESIRE Conference 2024 (Diabetes and Insulin Resistance Conference 2024)
野村和弘「Role of adrenergic signaling in skeletal muscle remodeling」
２．2022年度肥満・糖尿病クラスター・ミニリトリート
兵藤瑞沙「骨格筋萎縮のバイオマーカーとしての尿中タイチン測定の有用性」
１．2022年度肥満・糖尿病クラスター・ミニリトリート
待田京香「廃用性筋萎縮予防に関する分子栄養学的研究」
